Search Skin Biology

Hydrogels for Osteochondral
Tissue Engineering
Journal of Biomedical

(March 2020)
Anti-Wrinkle Activity
& Transdermal Delivery
of GHK Peptide
Journal of Peptide Science
(March 2020)
Pulsed Glow Discharge
to GHK-Cu Determination
International Journal
of Mass Spectrometry

(March 2020)
Protective Effects of GHK-Cu
in Pulmonary Fibrosis
Life Sciences
(January 2020)
Anti-Wrinkle Benefits
of GHK-Cu Stimulating
Skin Basement Membrane
International Journal
of Molecular Sciences

(January 2020)
Structural Analysis
Molecular Dynamics of
Skin Protective
TriPeptide GHK
Journal of Molecular Structure
(January 2020)
In Vitro / In Vivo Studies
pH-sensitive GHK-Cu in
Superabsorbent Polymer
GHK Enhances
Stem Cells Osteogenesis
Acta Biomaterialia
Antibacterial GHK-Cu
Nanoparticles for
Wound Healing
Particle & Particle (2019)
Effect of GHK-Cu
on Stem Cells and
Relevant Genes
OBM Geriatrics
GHK Alleviates
Neuronal Apoptosis Due
to Brain Hemorrhage
Frontiers in Neuroscience
Endogenous Antioxidant
International Journal of Pathophysiology and Pharmacology (2018)
Regenerative and
Protective Actions of
GHK-Cu Peptide
International Journal of
Molecular Sciences
Skin Regenerative and
Anti-Cancer Actions
of Copper Peptides
GHK-Cu Accelerates
Scald Wound Healing
Promoting Angiogenesis
Wound Repair and

GHK Peptide Inhibits
Pulmonary Fibrosis
by Suppressing TGF-B1
Frontiers in Pharmacology
Skin Cancer Therapy
with Copper Peptides
The Effect of Human
Peptide GHK Relevant to
Nervous System Function
and Cognitive Decline
Brain Sciences (2017)
Effects of Tripeptide
GHK in Pain-Induced
Aggressive Behavior
Bulletin of Experimental
Biology & Medicine
GHK-Cu Elicits
In Vitro Alterations
in Extracellular Matrix
Am Journal of Respiratory
and Critical Care Medicine

Selected Biomarkers &
Copper Compounds
Scientific Reports

GHK-Cu on Collagen,
Elastin, and Facial Wrinkles
Journal of Aging Science
Tri-Peptide GHK-Cu
and Acute Lung Injury

Effect of GHK Peptide
on Pain Sensitivity
Experimental Pharmacology

New Data of the
Cosmeceutical and
TriPeptide GHK
SOFW Journal
GHK Peptide as a
Natural Modulator of
Multiple Cellular Pathways
in Skin Regeneration
BioMed Research (2015)
Resetting Skin Genome
Back to Health
Naturally with GHK
Textbook of Aging Skin
GHK-Cu May Prevent
Oxidative Stress in Skin
by Regulating Copper and
Modifying Expression of
Numerous Antioxidant Genes Cosmetics (2015)
GHK Increases
TGF-B1 in
Human Fibroblasts

Acta Poloniae

The Human Skin Remodeling Peptide Induces Anti-Cancer
Expression and DNA Repair Analytical Oncology
Resetting the
Human Genome to Health
BioMed Research
Enhanced Tropic Factor Secretion of Mesenchymal
Stem Cells with GHK
Acta Biomater
Anxiolytic (Anti-Anxiety)
Effects of GHK Peptide
Bulletin of Experimental
Biology & Medicine
Lung Destruction and
its Reversal by GHK
Genome Medicine
TriPeptide GHK Induces
Programmed Cell Death
of Neuroblastoma
Journal of Biotechnology
Stem Cell
Recovering Effect
of GHK in Skin
Peptide Science
Skin Penetration of
Copper Tripeptide in Vitro
Journal of International
Inflammation Research
Possible Therapeutics
for Colorectal Cancer
Journal of Clinical and
Experimental Metastasis
Methods of Controlling
Differentiation and
Proliferation of Stem Cells
Effects of
Copper Tripeptide
on Irradiated Fibroblasts
American Medical Association
Avoid Buying Fake Copper Peptides Dangerous

The Art & Science of Skin Needling

If you look at a blemish, you will see that it is very different from surrounding skin. No matter what is the origin of the mark or what type of a scar it is—it will not have normal skin layers and will always be formed by rough, disorganized bundles of collagen.

All of this makes it very difficult to deliver active ingredients into this area. First, exfoliation removes the upper layer of dead skin cells, so that active ingredients can be absorbed much more easily. However, if you have thick damage, or if you simply want to ensure that copper peptides are delivered exactly where you want them, you may consider combining copper peptide products with a technique called at-home microneedling.

Medical needling has been used for many years by dermatologists to help trigger skin rejuvenation. Even though it is very effective, this type of skin needling must be performed in a clinical setting, requires anesthesia, and may lead to irritation and sometimes hyperpigmentation.

In contrast, microneedling is a gentler and much safer version of medical needling. It is a minimally invasive technique that uses very tiny needles to essentially create temporary pores. Microneedling devices are safe, very inexpensive, and can be used at home.

A recent scientific study confirmed microneedling to be a safe and effective way to deliver copper peptides into skin. The rate and depth of penetration of copper peptides increased with the force of application. So, if you have just started using copper peptides with a needling device, it is always best to be very gentle at first. Always listen to your skin, and when in doubt—start slowly and proceed with caution.

Microneedling in combination with using a client’s own platelet-rich plasma (which naturally contains GHK-Cu) was shown to be very effective in the treatment of atrophic marks. Others have reported success in treatment of stretch marks using microneedling. Forty women with stretch marks were divided to two groups—one was treated with microneedling and another with a combination of microdermabrasion and sonophoresis. The microneedling group showed much greater improvement compared to the second group. If in the “microdermabrasion plus sonophoresis” group, there was a 50% increase of collagen synthesis; in the “microneedling” group, there was a 90% increase!

Thinking about trying at-home microneedling? Let's review some important tips:

Skin Needling Plus Copper Peptides

First, always cleanse the area thoroughly with a gentle, neutral pH cleanser. Of course, your hands should be completely clean as well. If your skin is red, irritated, experiencing an active breakout (or if you have any skin condition), please use copper peptides and biological oils to soothe the skin until any irritation is reduced, and wait on actual skin needling.

Skin Needling FeaturesDepending on their skincare goals, many have successfully used skin rollers in various ways. Here is the best technique that works well for the majority:

1. Gently roll on thoroughly cleansed skin, letting the device do the work for you. Avoid pressing too hard or rolling too swiftly. Always start with minimal pressure, then increase when you are sure it is well tolerated.

2. After rolling, apply a light amount of a copper peptide product. Many choose copper peptide serums as they can easily be diluted with water before applying to the area.

3. If needed, soothe skin after rolling with a moisturizing biological oil (such as emu oil or squalane).

Skin microneedling can be safely performed on all skin colors and types. Those new to skin rolling should always start with a shorter length needle (0.5 mm is perfect for general facial use).

Finally, it is very important to give your skin a good rest between needling sessions. Usually once a week, or once every two weeks, achieves excellent results with no side effects. Regular use of copper peptide serums and oil moisturizers between sessions will help restore smoothness and suppleness to your skin.

Current Dermaroller and Skin Needling Device Research

Featured Topics

Reducing the Appearance of Scars and Blemishes

2. NEW PATENT: Dr. Pickart US Patent on Skin Remodeling (Issued May 22, 2012)

3. Recovery After Chemical Peels

4. General Information on Scars and Skin Blemishes

5. The Art & Science of Skin NeedlinG - WHAT TO USE AFTER MICRONEEDLING

6. Post Procedure Skin Recovery

8. Stretch Marks and Reducing their Appearance

9. Sun Damage and Sun Damage Marks


Questions or Advice?

Email Dr. Loren Pickart:

Call us at 1-800-405-1912 Monday through Friday (8 am to 6 pm) PST